Parameter balancing
for kinetic models of cell metabolism



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Parameter balancing is a computational method for obtaining consistent parameter sets for kinetic metabolic models. Experimentally measured values, when inserted into models directly, would be likely to yield incomplete and inconsistent parameter sets. Balanced parameter sets, computed from measured kinetic constants and other experimental data, are complete and consistent: they respect constraints between biochemical quantities and assumptions about typical ranges, represented by prior values and bounds.

On this website, users can apply parameter balancing to their own metabolic models. Aside from the metabolic model itself (in SBML or SBtab format), users can upload additional files describing (i) measured kinetic and other data, (ii) prior distributionss for different types of kinetic parameter, and (iii) configuration options for the balancing process. These optional data need to be provided in the SBtab format.

To get acquainted with parameter balancing, please read the documentation page and the manual.